Kettenmann-Xiang Lab

1.Prof. Helmut Kettenmann

• Ovesen PL, Juul-Madsen K, Telugu NS, Schmidt V, Frahm S, Radbruch H, Louth EL, Korshøj AR, Heppner FL, Diecke S, Kettenmann H, Willnow TE (2025) Alzheimer's Disease Risk Gene SORL1 Promotes Receptiveness of Human Microglia to Pro-Inflammatory Stimuli.. Glia;73:857-872.
• Bakina O, Conrad T, Mitic N, Vidal RO, Obrusnik T, Sai S, Nolte C, Semtner M, Kettenmann H. (2024) In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia. PLoS One. 19:e0302376
• Baum P, Beinhauer A, Zirwes L, Loenneker L, Jabs R, Narayanan RT, Oberlaender M, Seifert G, Kettenmann H, Steinhäuser C (2024) Activity dependent modulation of glial gap junction coupling in the thalamus.iScience. 27:111043
• Yalcin F, Haneke H, Efe IE, Kuhrt LD, Motta E, Nickl B, Flüh C, Synowitz M, Dzaye O, Bader M, Kettenmann H. (2024) Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma. Acta Neuropathol Commun.;12:50.
• Chen X, Zhao Y, Huang Y, Zhu K, Zeng F, Zhao J, Zhang H, Zhu X, Kettenmann H,Xiang X. (2023) TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages. Glia.;71:2679-2695.
• Kuhrt LD, Motta E, Elmadany N, Weidling H, Fritsche-Guenther R, Efe IE, Cobb O, Chatterjee J, Boggs LG, Schnauß M, Diecke S, Semtner M, Anastasaki C, Gutmann DH, Kettenmann H. (2023) Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia. Dis Model Mech. 16:dmm049861.
• Huang Y, Motta E, Nanvuma C, Kuhrt LD, Yuan Y, Xia P, Lubas M, Zhu S, Schnauss M, Qazi N, Hu F, Zhang H, Lei T, Synowitz M, Flüh C, Kettenmann H. (2022) Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model. Cell Rep. 39:110670.
• Huang Y, Zhang Q, Lubas M, Yuan Y, Yalcin F, Efe  IE, Xia P, Motta E, Buonfiglioli  A,  Lehnardt  S, Dzaye  O, Flueh C, Synowitz M, Hu F, Kettenmann H  (2020) Synergistic Toll-like Receptor 3/9 Signaling Affects Properties and Impairs Glioma-Promoting Activity of Microglia . J Neurosci 40:6428-6443.

• Zhang L^#, Xiang X^#*, Li Y, Bu G, Chen XF*. TREM2 and sTREM2 in Alzheimer's disease: from mechanisms to therapies. Mol Neurodegener. 2025 Apr 17;20(1):43. （co-corresponding author）
• Chen X, Zhao Y, Huang Y, Zhu K, Zeng F, Zhao J, Zhang H, Zhu X, Kettenmann H*, Xiang X*. TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages. Glia.2023 Nov;71(11):2679-2695. （co-corresponding author）
• Xiang X, et al. Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases. Science Translational Medicine. 2021 Oct 13;13(615):eabe5640. （First author）
• Xiang X, Tahirovic S, Ziegler S, Haass C, Brendel M*. Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases". Science Translational Medicine. 2022 Aug 24;14(659):eabn5104（First author）
• Xiang X, et al. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Molecular Neurodegeneration. 2018 Sep 6;13(1):49. （First author）
• Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO Molecular Medicine. 2016 Sep 1;8(9):992-1004. （First author）
• Zhao J, Liu S, Xiang X*, Zhu X*. Versatile strategies for adult neurogenesis: avenues to repair the injured brain. Neural Regeneration Research. 2024 Apr;19(4):774-780. （co-corresponding author）
• Zhu K, Xiang X, Filser S, et al. Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biological Psychiatry. 2018 Mar 1;83(5):428-437.
• Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, et al. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease. Molecular Neurodegeneration. 2024 Sep 5;19(1):64.